Obesity-related cardiovascular disease: implications of obstructive sleep apnea
1Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55902, USA.
Abstract:
Obesity and obstructive sleep apnea (OSA) often coexist. OSA has been linked to cardiovascular disease. Thus, OSA may contribute to the cardiovascular consequences of obesity. In this review, we explore clinical and pathophysiological interactions between obesity, cardiovascular disease and OSA. We discuss the mechanisms whereby OSA may contribute to hypertension, atherosclerosis, insulin resistance and atrial fibrillation associated with obesity, and emphasize the potential implications for understanding why only a subgroup of obese patients develop cardiovascular disease. Identification of the OSA-dependent and OSA-independent pathways in the cardiovascular pathophysiology of obesity may hold clinical and therapeutic promise.
Related Concept Videos
Sleep Apnea
The condition is more prevalent among...
Coronary Artery Disease I: Introduction
Obesity
Other Pulmonary Disorders
Stress Prevention and Stress Management Techniques IV
Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
