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Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
Published on: May 23, 2014
[Study of differential gene expression in different stage human endometrial cancer]
Xiao-ping Wan1, Bin Cai, Ling Liu
1Department of Obstetrics and Gynecology, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China.
Objective:
To study the gene expression profile of different stage endometrial cancer and identify genes related to the progression and metastasis of endometrial cancer.
Methods:
cDNA microarray was used to analyze the differentially expressed genes between different stage endometrial cancers. The hierarchical cluster analysis was applied to the gene expression profile of 32 endometrial cancers.
Results:
Twelve differentially expressed genes were identified between different stage endometrial cancers. The conformity rate was 66% between the result of hierarchical cluster analysis and the operative-histological stages of International Federation of Gynecology and Obstetrics (FIGO).
Conclusion:
Genes related to the endometrial cancer progression and metastasis can be identified by differential gene expression profile with cDNA microarray and high-risk endometrial cancer may be distinguished before surgery by hierarchical cluster analysis.