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Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice
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Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice

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New molecular mechanism in diastolic heart failure

Arnold M Katz, Michael R Zile

    Circulation
    |April 26, 2006
    PubMed
    Abstract

    No abstract available in PubMed .

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    Pathophysiology of Heart Failure01:17

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    Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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    Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

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