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Updated: Aug 7, 2026
A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
Published on: November 13, 2016
Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complex
J Y Wu1, W W Sutherling, S Koh
1Division of Pediatric Neurology, The Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. joycewu@mednet.ucla.edu
Abstract:
The authors assessed whether magnetoencephalography/magnetic source imaging (MEG/MSI) identified epileptogenic zones in patients with tuberous sclerosis complex (TSC). In six TSC children with focal seizures, ictal video-EEG predicted the region of resection with 56% sensitivity, 80% specificity, and 77% accuracy (p = 0.02), whereas interictal MEG/MSI fared better (100%, 94%, and 95%, respectively; p < 0.0001). Interictal MEG/MSI seems to identify epileptogenic zones more accurately in children with TSC and focal intractable epilepsy.
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