The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection
M Longoni1, C Grond-Ginsbach, A J Grau
1Department of Neurology, University of Milano-Bicocca, Monza, Monza, Italy. longonimarco@hotmail.com
Abstract:
In a primary study on proinflammatory genetic profiles in stroke, the authors found the E469K polymorphism of the intercellular adhesion molecule 1 (ICAM-1) highly represented in the subgroup with spontaneous cervical artery dissection (sCAD). They further investigated the same genetic variant in a second group of 65 patients with sCAD. An association between sCAD and EE genotype was confirmed (odds ratio 3.16; p < 0.01), indicating that a proinflammatory predisposition is a risk factor for sCAD.
More Related Videos
Related Concept Videos
Immunoglobulin-like Cell Adhesion Molecules
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT


