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Related Experiment Videos

Identification of a suitable current waveform for acute stroke imaging.

A Romsauerova1, A McEwan, D S Holder

  • 1Department of Medical Physics and Bioengineering, UCL, London, UK. a.romsauerova@ucl.ac.uk

Physiological Measurement
|April 26, 2006
PubMed
Summary
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Multi-frequency electrical impedance tomography (MFEIT) is a promising portable neuroimaging technique. Researchers found that reducing or removing low frequencies (below 100 Hz) in MFEIT current patterns prevents uncomfortable skin sensations during brain imaging.

Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Neuroscience

Background:

  • Multi-frequency electrical impedance tomography (MFEIT) offers a portable, non-invasive neuroimaging solution for acute stroke.
  • Previous MFEIT applications above 2 kHz did not cause skin perception.
  • Brain imaging with MFEIT requires currents below 100 Hz, potentially stimulating cutaneous nerves.

Purpose of the Study:

  • To determine the optimal current pattern for MFEIT brain imaging using the UCLH Mk2.5 system.
  • To identify a current pattern that avoids uncomfortable skin sensations in adult subjects.
  • To ensure MFEIT's suitability for non-invasive neuroimaging in clinical settings.

Main Methods:

  • Applied single-frequency currents (20-80 Hz, 0.28 mA) to volunteers' forearms, noting perception thresholds.

Related Experiment Videos

  • Administered a full frequency pattern (20 Hz-1.6 MHz, 0.28 mA) to forearms and heads of healthy subjects.
  • Systematically attenuated or removed low frequencies (below 100 Hz) to assess impact on perceived sensation.

    • Main Results:

    • Single low-frequency currents (20-80 Hz) were not perceived, even on abraded skin.
    • A full frequency pattern induced an unpleasant tingling sensation due to current summation.
    • Reducing or removing frequencies below 100 Hz significantly decreased or abolished the sensation.
    • An optimal pattern excluded 40 Hz and reduced 80 Hz and 20 Hz components to 75% and 50% respectively.

    Conclusions:

    • MFEIT current patterns must be optimized to prevent cutaneous nerve stimulation for brain imaging.
    • Excluding or attenuating frequencies below 100 Hz is crucial for subject comfort.
    • The identified optimal current pattern balances MFEIT imaging requirements with patient safety and comfort.