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Published on: January 5, 2017
Reactive oxygen metabolites and colitis: a disturbed balance between damage and protection. A selective review
H W Verspaget1, T P Mulder, A van der Sluys Veer
1Dept. of Gastroenterology and Hepatology, University Hospital, Leiden, The Netherlands.
Abstract:
Enhanced local production of reactive oxygen metabolites has been found in association with colitis, both experimentally and in humans. Cellular and biochemical systems involved have been identified, and 5-aminosalicylic acid-containing drugs but, more effectively, specific scavengers have been found to reduce the intestinal inflammatory process. The multitude of reactions in which oxygen metabolites participate provides a new area of research in intestinal inflammation. These basic studies might bring related clinical studies in an era of new anti-inflammatory drugs for inflammatory bowel disease specifically designed to scavenge toxic oxygen metabolites.
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