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Updated: Aug 9, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Catalytic asymmetric approaches towards enantiomerically enriched diarylmethanols and diarylmethylamines
Frank Schmidt1, René T Stemmler, Jens Rudolph
1Institut für Organische Chemie der RWTH Aachen, Landoltweg 1, 52074 Aachen, Germany. Carsten.Bolm@oc.rwth-aachen.de
Abstract:
Enantiopure diarylmethanols and diarylmethylamines are important intermediates for the synthesis of pharmaceutically relevant products with antihistaminic, antiarrhythmic, diuretic, antidepressive, laxative, local-anesthetic and anticholinergic properties. Furthermore, they have been used as precursors for 1,1-diarylalkyl moieties, which occur in other antidepressants as well as in antimuscarinics and endothelin antagonists. In this critical review catalytic strategies towards enantioenriched diarylmethanols and diarylmethylamines are discussed, including methods for asymmetric carbon-carbon bond formations by aryl transfer reactions to aldehydes and arylimines, respectively, and enantioselective reductions of diarylketones.
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