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Lignans from Saussurea conica and their NO production suppressing activity
Cheng-Qi Fan1, Xing-Zu Zhu, Zha-Jun Zhan
1State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P. R. China.
Abstract:
Three new lignan derivatives, conicaols A and B and conicaoside, together with seven known compounds were identified from Saussurea conica. Their structures were elucidated by spectral methods including 1D and 2D NMR techniques. Six 2,3-dibenzylbutyrolactone-type lignans were biologically evaluated, and two of them, arctigenin and matairesinol, showed potent activity to suppress NO production in vitro in LPS-activated macrophages of SD rat.
