Related Experiment Video

Updated: Aug 9, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
06:21

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Published on: May 10, 2024

Germline ATBF1 mutations and prostate cancer risk

Junyan Xu1, Jurga Sauvageot, Charles M Ewing

  • 1Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

The Prostate
|April 26, 2006
PubMed
Abstract

Insights

The germline 3381del allele of the ATBF1 gene may increase prostate cancer risk. This finding suggests ATBF1 may be a prostate tumor suppressor gene, influencing susceptibility in sporadic cases.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • ATBF1 is a candidate prostate tumor suppressor gene.
  • Two recurrent somatic mutations, Poly(T)n and 3381del, impact ATBF1 function and expression in prostate cancer.
  • These mutations were observed in multiple prostate cancer samples.

Purpose of the Study:

  • To investigate the germline origin and prostate cancer risk associated with two recurrent ATBF1 sequence variants.
  • To determine if carriers of these variants have an increased risk for prostate cancer.

Main Methods:

  • Assayed two recurrent sequence variants (Poly(T)n and 3381del) in germline DNA from prostate cancer cases and controls.
  • Genotyped germline DNA samples to assess the association with prostate cancer risk.

Main Results:

  • Poly(T)n variants were found in both normal and tumor DNA, confirming germline origin.
  • The 3381del variant was significantly associated with increased prostate cancer risk in sporadic cases (P = 0.03).
  • No significant association was found between 3381del and prostate cancer risk in hereditary cases.

Conclusions:

  • The germline 3381del allele of ATBF1 may influence prostate cancer susceptibility.
  • ATBF1 germline variants could play a role in the development of prostate cancer.

More Related Videos

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA108:53

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration06:21

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration

Published on: April 27, 2018

Related Concept Videos

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Probability Laws01:49

Probability Laws

Overview
Mutations01:39

Mutations

Overview
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...