Related Experiment Video
Updated: May 6, 2026
09:16
Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR
Published on: February 5, 2018
5.6K
[Stanniocalcin-1 (STC-1) as a molecular marker for human cancer]
1Department of Infection Control and Laboratory Diagnostics, Tohoku University, Graduate School of Medicine, Sendai 980-8574.
Rinsho Byori. the Japanese Journal of Clinical Pathology
|April 28, 2006
Summary
Stanniocalcin-1 (STC-1) mRNA in blood indicates cancer. High STC-1 levels correlate with tumor size and disease presence, suggesting its use as a cancer biomarker.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Context:
- Stanniocalcin-1 (STC-1), a glycoprotein hormone regulating calcium, is expressed in various human organs.
- STC-1 expression is linked to cellular processes like differentiation, bone formation, and proliferation.
Purpose:
- To review the diagnostic significance of STC-1 as a molecular marker for human cancer.
- To highlight the association between STC-1 mRNA levels in blood and cancer presence.
Summary:
- Quantitative RT-PCR revealed elevated STC-1 mRNA in cancer patients' blood compared to healthy volunteers.
- STC-1 mRNA levels correlate with tumor size in breast cancer, micrometastases in hepatocellular carcinoma, and minimal residual disease in leukemia.
Impact:
- STC-1 shows potential as a non-invasive diagnostic biomarker for various human cancers.
- Further research into STC-1 could lead to improved cancer detection and monitoring strategies.
