Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diffuse granulomatous necrotizing scleritis.

Irene Pecorella1, Maurizio La Cava, Giuseppe Mannino

  • 1Department of Experimental Medicine and Pathology, University of Rome, Rome, Italy. irene.pecorella@uniroma1.it

Acta Ophthalmologica Scandinavica
|April 28, 2006
PubMed
Summary

This case report details a patient with scleritis potentially caused by Wegener's granulomatosis (WG), highlighting the importance of early diagnosis and treatment for ocular manifestations of systemic autoimmune diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Qualitative and Quantitative Assessment of Vitreous Inflammation in Uveitis: Current Limitations and Emerging Diagnostic Approaches.

Diagnostics (Basel, Switzerland)·2026
Same author

Transcriptomic landscapes of tissue-specific color transition in eggplant reveal regulatory roles of lncRNAs and alternative splicing in anthocyanin biosynthesis.

Frontiers in plant science·2026
Same author

Leonardite-derived humic substances enhance phosphorus use efficiency in lettuce through integrated physiological and metabolic reprogramming.

Frontiers in plant science·2026
Same author

Sub-chronic exposure to nanoplastics in vitro disrupts hepatic lipid homeostasis in human hepatocytes.

Toxicology·2026
Same author

Fellow-eye herpes simplex virus type 1 uveitis after intravitreal bevacizumab: a case report.

BMC ophthalmology·2026
Same author

Reduced geomagnetic field modulates photosynthetic electron flow, menthol yield, flavonoid photoprotection and ROS homeostasis in peppermint (Mentha × piperita L.).

Plant physiology and biochemistry : PPB·2026

Area of Science:

  • Ophthalmology
  • Rheumatology
  • Immunology

Background:

  • Posterior scleritis can occur without systemic autoimmune disease.
  • Wegener's granulomatosis (WG) is a systemic vasculitis that can affect the eyes.

Observation:

  • A 34-year-old man presented with progressive scleritis, optic disc edema, and macular edema.
  • Ocular findings included scleral thinning, epiretinal neovascularization, nasal septum perforation, and vitreous hemorrhage.
  • Histopathology revealed necrotizing granulomatous tissue.

Findings:

  • The patient's presentation was most consistent with Wegener's granulomatosis (WG).
  • Ocular involvement in WG is common, affecting up to 58% of cases.
  • Prompt diagnosis and treatment are crucial for managing severe necrotizing posterior scleritis.

Related Experiment Videos

Implications:

  • Comprehensive evaluation including medical history, imaging, and serology is essential for diagnosing scleritis.
  • Cyclophosphamide is the preferred treatment for ocular manifestations of WG, polyarteritis nodosa, and rheumatoid arthritis.
  • Aggressive treatment can help prevent vision loss in severe cases of scleritis.