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Updated: Jul 31, 2026

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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
Published on: February 7, 2015
Laser Doppler perfusion imaging: a method for measuring female sexual response
S J Styles1, A B Maclean, W M N Reid
1University Department of Obstetrics and Gynaecology, Hampstead Campus, The Royal Free and University College Medical School, London, UK.
Summary
Laser Doppler perfusion imaging (LDPI) noninvasively measured vulval blood flow changes during sexual arousal. This technique shows potential for diagnosing female sexual dysfunction and evaluating treatment efficacy.
Area of Science:
- Physiology
- Medical Imaging
Background:
- Assessing female sexual response requires objective physiological measures.
- Current methods for measuring genital blood flow are often invasive or lack precision.
Purpose of the Study:
- To develop and validate a noninvasive technique for quantifying vulval blood flow changes during sexual arousal.
- To establish the utility of laser Doppler perfusion imaging (LDPI) in this context.
Main Methods:
- 18 healthy female volunteers (ages 20-33) participated in two sessions across menstrual cycle phases.
- Laser Doppler perfusion imaging (LDPI) was used to scan vulval perfusion before and after erotic stimuli.
- Percentage changes in blood flow flux were calculated for clitoral, labial, and posterior fourchette regions.
Main Results:
- Significant increases in blood flow were observed: clitoral skin (26.4%), labial skin (24.9%), and posterior fourchette (35.3%).
- All increases were statistically significant (P < 0.05).
Conclusions:
- Laser Doppler perfusion imaging (LDPI) effectively detects changes in vulval perfusion during sexual arousal.
- This noninvasive method holds promise for clinical applications in female sexual dysfunction research and treatment assessment.

