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Related Experiment Videos

Bilateral breast cancer: one disease or two?

P J Dawson1, T Maloney, P Gimotty

  • 1Department of Pathology, University of Chicago, IL.

Breast Cancer Research and Treatment
|November 1, 1991
PubMed
Summary
This summary is machine-generated.

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Bilateral breast cancer likely arises from independent events rather than genetic predisposition. Most cases show no tumor concordance, family history, or early onset, suggesting sporadic origins.

Area of Science:

  • Oncology
  • Genetics
  • Pathology

Background:

  • Bilateral breast cancer presents a diagnostic challenge, requiring differentiation between genetic predisposition and independent sporadic events.
  • Understanding the origins of bilateral breast cancer is crucial for accurate diagnosis, treatment, and genetic counseling.

Purpose of the Study:

  • To investigate whether bilateral breast cancer originates from a shared genetic predisposition or represents two distinct sporadic tumor developments.
  • To evaluate biological concordance, family history, and clinical factors in patients with bilateral breast cancer.

Main Methods:

  • Compared histopathology and immunocytochemical marker reactivity (six markers) in paired bilateral tumors from 51 patients.
  • Assessed family history of breast cancer, age at diagnosis, and survival in 88 patients with bilateral breast cancer.

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Main Results:

  • No significant concordance was observed in histologic patterns or immunocytochemical reactions between paired bilateral tumors, except for estrogen receptors.
  • Absence of concordance, lack of association with positive family history, and early age of onset were noted.

Conclusions:

  • The findings suggest that bilateral breast cancer predominantly arises from independent sporadic events.
  • A major role for genetic determinants in the majority of bilateral breast cancer cases is not supported by this study.