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Implantation of Osmotic Pumps and Induction of Stress to Establish a Symptomatic, Pharmacological Mouse Model for DYT/PARK-ATP1A3 Dystonia
Published on: September 12, 2020
[A study on outcome of surgical treatment for focal dystonia]
Yu-qing Zhang1, Yong-jie Li, Xiao-hua Zhang
1Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China. yuqzhang@sohu.com
Objective:
To analysis the outcome of stereotactic nucleus lesioning for focal dystonia patients.
Methods:
Twenty-three focal dystonia patients were divided into 2 groups according to etiological factor. Stereotactic nucleus lesioning was performed for 10 primary dystonia patients of group A and 13 secondary patients of group B. The change of motor function was investigated and matched between 2 groups after 6 months follow-up.
Results:
Significant improvement of motor abilities was observed in patients of group A. The mean improvement of patients of group B was 43.8%. And the individual difference of improvement was obvious in patients of group B.
Conclusions:
Stereotactic nucleus lesioning displays a satisfactory therapeutic effect for patients of writer's cramp. The efficacy of nucleus lesioning for secondary focal dystonia patients depends on the extensive of brain functional lesion. A structurally normal brain is not certainly a predictor of good response to surgical treatment.
