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Updated: Jul 27, 2026

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
Published on: June 12, 2021
The PediaFlow pediatric ventricular assist device
Peter D Wearden1, Victor O Morell, Bradley B Keller
1Section of Pediatric Cardiothoracic Surgery of the Heart Lung and Esophageal Institute, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Insights
Pediatric ventricular assist devices (VADs) are being developed to treat heart failure in children. This innovative PediaFlow VAD uses magnetic levitation to minimize blood trauma and thrombosis risk.
Area of Science:
- Biomedical Engineering
- Pediatric Cardiology
- Medical Device Development
Background:
- Limited treatment options exist for pediatric ventricular failure.
- Congenital and acquired heart diseases pose significant risks to children.
- Development of a pediatric ventricular assist device (VAD) is crucial.
Purpose of the Study:
- To develop a reliable and biocompatible VAD for chronic support in pediatric patients.
- To address the unique needs of children weighing 3-15 kg (birth to 2 years).
- To minimize blood trauma and thrombosis risk in pediatric VADs.
Main Methods:
- Development of the PediaFlow VAD, a miniature mixed-flow turbodynamic pump.
- Utilizing magnetic levitation technology for pump operation.
- Collaboration between academic institutions and industry partners.
Main Results:
- The PediaFlow VAD design focuses on minimizing blood trauma.
- Magnetic levitation aims to reduce the risk of thrombosis.
- Ongoing development by a dedicated consortium.
Conclusions:
- The PediaFlow VAD represents a significant advancement in pediatric cardiac support.
- The device aims to provide a reliable solution for chronic ventricular failure in children.
- Further development is underway to address critical needs in pediatric cardiology.
Abstract:
The very limited options available to treat ventricular failure in patients with congenital and acquired heart diseases have motivated the development of a pediatric ventricular assist device (VAD). Our effort involves a consortium consisting of the University of Pittsburgh, Carnegie Mellon University, Children's Hospital of Pittsburgh, World Heart Corporation, and LaunchPoint Technologies, LLC. The overall aim of our program is to develop a highly reliable, biocompatible VAD for chronic support (6 months) of the unique and high-risk population of children between 3 kg and 15 kg (patients from birth to 2 years of age). The innovative pediatric VAD we are developing (PediaFlow) is based on a miniature mixed-flow turbodynamic pump featuring magnetic levitation, with the design goal being to assure minimal blood trauma and risk of thrombosis. This article discusses the limitations of current pediatric cardiac assist treatment options and the work to date by our consortium toward the development of a pediatric VAD.
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