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Renal cell carcinoma producing granulocyte colony-stimulating factor.
Yen-Chieh Wang1, Stone Yang, Chin-Yuan Tzen
1Department of Urology, Mackay Memorial Hospital, Taipei, Taiwan.
Journal of the Formosan Medical Association = Taiwan Yi Zhi
|April 28, 2006
Summary
Renal cell carcinoma can rarely cause severe neutrophilia by secreting granulocyte colony-stimulating factor (G-CSF). Monitoring white blood cell count is crucial for detecting disease activity in G-CSF-producing renal cell carcinoma.
Area of Science:
- Oncology
- Hematology
- Endocrinology
Background:
- Renal cell carcinoma (RCC) is a rare cause of severe neutrophilia.
- Neutrophilia can be associated with elevated serum levels of granulocyte colony-stimulating factor (G-CSF).
Observation:
- A 70-year-old woman presented with anemia, severe neutrophilia, and elevated serum G-CSF.
- These symptoms resolved after radical nephrectomy for a high-grade, stage pT1N0M0 RCC.
- Tumor cells stained positive for G-CSF via immunohistochemistry.
Findings:
- Preoperative serum G-CSF levels were elevated and normalized postoperatively.
- A recurrence 17 months later was detected by monitoring white blood cell count and physical examination.
- Serum G-CSF levels and white blood cell count correlated with tumor growth.
Implications:
- White blood cell count serves as a valuable indicator of disease activity in patients with G-CSF-producing RCC.
- Close monitoring of white blood cell count can facilitate timely detection of tumor recurrence.
- This case highlights the importance of considering paraneoplastic syndromes in cancer diagnosis and management.