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Related Experiment Videos

Early detection of schizophrenia.

Richard J Drake1, Shôn W Lewis

  • 1Division of Psychiatry, University of Manchester, Manchester, UK.

Current Opinion in Psychiatry
|April 28, 2006
PubMed
Summary

Early detection of psychosis and schizophrenia is feasible. Interventions for at-risk mental states show promise, but benefits for reducing untreated psychosis duration require further demonstration.

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Area of Science:

  • Psychiatry
  • Mental Health Research
  • Clinical Psychology

Background:

  • Schizophrenia incidence rates may be more variable than previously understood.
  • Current diagnostic approaches may not capture all at-risk individuals early.
  • The duration of untreated psychosis is a critical factor in schizophrenia outcomes.

Purpose of the Study:

  • To evaluate the rationale for earlier detection of psychosis and schizophrenia.
  • To assess the feasibility of implementing early detection strategies.
  • To review recent advancements in identifying and intervening in early psychosis.

Main Methods:

  • Review of operational criteria for prodromal or at-risk mental states.
  • Analysis of randomized trials for interventions in at-risk populations.
  • Examination of studies on the duration of untreated psychosis in first-episode schizophrenia.

Main Results:

  • Operational criteria identify 20-40% of at-risk individuals transitioning to psychosis within 1 year.
  • Early antipsychotic and psychological interventions show promising results in reducing psychosis transition.
  • A correlation exists between duration of untreated psychosis and clinical outcome, though causality is debated.

Conclusions:

  • Early detection of psychosis appears feasible.
  • Interventions for at-risk mental states demonstrate potential benefits.
  • The definitive advantages of shortening the duration of untreated psychosis are not yet conclusively proven.

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