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Related Experiment Videos

Phototoxic potential of quinolones.

A M Cárdenas1, F Vargas, E Fernández

  • 1Laboratorio de Fotobiologia y Fotoquimica, Facultad de Medicina, Universidad de Valparaiso, Chile.

Journal of Photochemistry and Photobiology. B, Biology
|August 1, 1991
PubMed
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Certain quinolone antibiotics, like oxolinic acid, can cause photohaemolysis, a light-induced red blood cell damage. This effect, mediated by singlet oxygen, is inhibited by antioxidants and depends on drug concentration and oxygen levels.

Area of Science:

  • Pharmacology
  • Photobiology
  • Medicinal Chemistry

Background:

  • Quinolones are a class of antibiotics with diverse chemical structures.
  • Some quinolones are known to induce phototoxicity, a harmful reaction to light.
  • The mechanism of quinolone-induced photohaemolysis requires further elucidation.

Purpose of the Study:

  • To evaluate and compare the photohaemolytic potentials of various quinolone compounds.
  • To investigate the role of chemical structure, specifically the piperazine group, in quinolone phototoxicity.
  • To elucidate the mechanism underlying quinolone-induced photohaemolysis.

Main Methods:

  • Photohaemolysis assays were conducted using different quinolone compounds.
  • Concentration- and oxygen-dependency of photohaemolysis were assessed.

Related Experiment Videos

  • The effects of potential inhibitors (ascorbic acid, histidine, thiourea) and deuterium oxide were evaluated.

    • Main Results:

    • Quinolones with a piperazine group at position 7 (pipemidic acid, norfloxacin, ciprofloxacin) did not induce photohaemolysis.
    • Oxolinic acid, rosoxacin, and M-193324 demonstrated concentration- and oxygen-dependent photohaemolysis.
    • Photohaemolysis induced by oxolinic acid, rosoxacin, and M-193324 was inhibited by antioxidants and enhanced by deuterium oxide, suggesting a singlet oxygen-mediated photodynamic process.

    Conclusions:

    • The presence of a piperazine group at position 7 in quinolones prevents photohaemolysis.
    • Oxolinic acid, rosoxacin, and M-193324 exhibit photohaemolytic activity via a photodynamic mechanism.
    • Singlet oxygen plays a critical role in quinolone-induced photohaemolysis.