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Related Experiment Videos

Hippocampus function predicts severity of post-traumatic stress disorder.

Robert S Astur1, Sarah A St Germain, David Tolin

  • 1Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut 06106, USA. rastur@harthosp.org

Cyberpsychology & Behavior : the Impact of the Internet, Multimedia and Virtual Reality on Behavior and Society
|April 28, 2006
PubMed
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Post-traumatic stress disorder (PTSD) is linked to reduced hippocampal activity. This study suggests the virtual Morris Water task can identify individuals at risk for developing PTSD by assessing hippocampal function.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Post-traumatic stress disorder (PTSD) is associated with memory deficits and hippocampal abnormalities.
  • The hippocampus plays a crucial role in memory and spatial navigation.

Purpose of the Study:

  • To investigate hippocampal function in individuals with PTSD using a cross-species virtual Morris Water task.
  • To correlate hippocampal activity during the task with PTSD severity.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to measure hippocampal activity.
  • Participants with PTSD and age-matched controls completed a virtual Morris Water task.
  • fMRI data were correlated with PTSD severity scores.

Main Results:

Related Experiment Videos

  • Task performance was similar between individuals with PTSD and controls.
  • A strong negative correlation (-0.84) was found between hippocampal activity and PTSD severity.
  • This association remained significant regardless of task performance, IQ, or trauma history.

Conclusions:

  • Hippocampal function, assessed via the virtual Morris Water task, is inversely related to PTSD severity.
  • This task shows potential for identifying individuals at risk for PTSD.
  • Reduced hippocampal activity may be a biomarker for PTSD severity.