Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Influence of propolis water solution on heart mitochondrial function.

Daiva Majiene1, Sonata Trumbeckaite, Arunas Savickas

  • 1Institute for Biomedical Research, Kaunas University of Medicine, Eiveniu str.4, LT-50009 Kaunas-7, Lithuania. daivamaj@vector.kmu.lt

The Journal of Pharmacy and Pharmacology
|April 28, 2006
PubMed
Summary

Propolis water solution (PWS) significantly impairs mitochondrial respiration, particularly with succinate substrate. Higher PWS concentrations reduce respiration rates, impacting energy production in heart mitochondria.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Formulation and Characterisation of an Edible Functional Elderflower Extract Gel for Upper Respiratory Tract Soothing.

Gels (Basel, Switzerland)·2026
Same author

Propolis as an alternative remedy for the treatment of subclinical mastitis in dairy cows.

Frontiers in veterinary science·2026
Same author

Changes in the Amino Acid Composition of Bee-Collected Pollen During 15 Months of Storage in Fresh-Frozen and Dried Forms.

Foods (Basel, Switzerland)·2026
Same author

Effect of Fireweed (<i>Chamerion angustifolium</i> L.) Extracts and Oenothein B on Colon Cancer Cells: Impact of Leaf Fermentation on Viability and Mitochondrial Function.

Medicina (Kaunas, Lithuania)·2025
Same author

Examining the Role of Extraction Techniques and Regional Variability in the Antioxidant and Phytochemical Composition of <i>Juglans regia</i> L. Septa.

Plants (Basel, Switzerland)·2025
Same author

Cyano-phycocyanin loaded enriched transfersomes for enhanced topical skin delivery and antioxidant protection.

International journal of pharmaceutics·2025

Area of Science:

  • Biochemistry
  • Cellular Respiration
  • Mitochondrial Function

Background:

  • Mitochondria are crucial for cellular energy production.
  • Propolis, a natural resin, has various biological activities.
  • Understanding propolis's effects on cellular metabolism is important.

Purpose of the Study:

  • To investigate the impact of propolis water solution (PWS) on rat heart mitochondrial respiration.
  • To determine the dose-dependent effects of PWS on different respiratory substrates.
  • To elucidate potential mechanisms of PWS-induced mitochondrial dysfunction.

Main Methods:

  • Isolated rat heart mitochondria were used.
  • Mitochondrial respiration was measured using NAD-linked (pyruvate + malate), FAD-linked (succinate) substrates, and fatty acids (palmitoyl-L-carnitine).

Related Experiment Videos

  • The effects of varying PWS concentrations (based on phenolic compounds, PC) were assessed.

    • Main Results:

    • PWS at 4 microg mL(-1) PC showed no effect on mitochondrial respiration.
    • PWS at 63 and 125 microg mL(-1) PC significantly decreased basal and maximal respiration rates with succinate (24-70% reduction).
    • Respiration with pyruvate + malate and palmitoyl-L-carnitine was less affected (13-28% reduction).
    • Inhibition of succinate dehydrogenase by esters in PWS may explain succinate oxidation effects.
    • Reduced activity of respiratory chain complexes or ADP/ATP translocator might explain effects with other substrates.

    Conclusions:

    • Propolis water solution exhibits inhibitory effects on mitochondrial respiration in a dose-dependent manner.
    • Succinate oxidation is particularly sensitive to PWS, likely due to succinate dehydrogenase inhibition.
    • PWS may impair cellular energy production by affecting mitochondrial respiratory chain complexes and/or ADP/ATP translocator.