Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Two different genetic analyses of spontaneously aborted specimen].

Ya-li Hu1, Xue Chen, Lei-lei Chen

  • 1Department of Obstetrics and Gynecology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.

Zhonghua Fu Chan Ke Za Zhi
|April 28, 2006
PubMed
Summary

Comparative genomic hybridization (CGH) is a feasible method for analyzing spontaneously aborted tissue. This technique successfully identified chromosomal abnormalities in cases where conventional karyotyping failed, aiding in understanding spontaneous abortion causes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Itaconate as a paracrine brake on thermogenesis.

Nature metabolism·2026
Same author

The antimicrobial arsenal of endophytes in Lilium pumilum: active components of Fusarium tricinctum and antifungal mechanisms.

Archives of microbiology·2026
Same author

In situ cultivation and chromogenic screening: a dual approach for rapid discovery of PDE1 inhibitors from pinus-tree associated microbes.

World journal of microbiology & biotechnology·2026
Same author

TLC-Bioautography-Guided Natural Product Discovery: An Integrated Platform for Rapid Profiling of Plant-Derived Phosphodiesterase Inhibitors.

Phytochemical analysis : PCA·2026
Same author

Prophylactic use of a combination of palonosetron hydrochloride and dexamethasone to prevent transcatheter arterial chemoembolization-induced nausea and vomiting among patients with hepatocellular carcinoma.

Frontiers in medicine·2026
Same author

Salusin α counteracts salusin β to attenuate artery medial calcification through the inhibition of oxidative stress and extracellular signal-regulated protein kinases signaling pathway in rats with chronic kidney disease.

The Journal of pharmacology and experimental therapeutics·2026

Area of Science:

  • Reproductive biology
  • Genetics
  • Medical diagnostics

Background:

  • Spontaneous abortion affects a significant number of pregnancies.
  • Identifying chromosomal abnormalities is crucial for understanding the causes of spontaneous abortion.
  • Conventional cytogenetic karyotyping has limitations in analyzing spontaneously aborted tissues.

Purpose of the Study:

  • To evaluate the feasibility of comparative genomic hybridization (CGH) for analyzing spontaneously aborted tissue.
  • To compare the efficacy of CGH with conventional cytogenetic karyotyping in detecting chromosomal abnormalities in early pregnancy loss.

Main Methods:

  • Thirty-eight cases of spontaneous abortion (gestational age 49-91 days) were analyzed.
  • Chorionic villi specimens were collected and subjected to both conventional cytogenetic karyotyping and CGH analysis.

Related Experiment Videos

  • The study aimed to detect chromosomal unbalanced abnormalities in the tissue specimens.

    • Main Results:

    • CGH analysis was successful in all 38 cases, while conventional karyotyping failed in 7 cases.
    • CGH and conventional karyotyping yielded identical results in 90% (28/31) of cases.
    • CGH identified abnormalities in 3 cases where karyotyping results were discrepant or failed, including aneuploidy in cases with failed karyotyping.

    Conclusions:

    • Comparative genomic hybridization (CGH) is a feasible and effective method for identifying chromosomal unbalanced abnormalities in spontaneous abortions.
    • CGH offers advantages over conventional karyotyping, particularly in cases where karyotyping is unsuccessful.
    • This technique aids in the etiological investigation of spontaneous pregnancy loss.