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[Influences of orthodontic tooth movement on estrous cycle and estrogen in rats]
1Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Objective:
To explore the influences of orthodontic tooth movement on estrous cycle and estrogen in female rats.
Methods:
Two hundred female rats were divided into control group, one-time activation group, four-time activation group and sham-operated group. Each group was divided again into 4 sub-groups according to the different stage of the estrous cycle. The force-loading groups received repeated intermittent force. Serum estrogen was measured and the change of estrous cycle was recorded.
Results:
There were significant variations in the estrogen level among the groups which received mechanical force during the same stage of the estrous cycle (P < 0.01) and among the subgroups within each group (P < 0.05). These experimental treatments affected the estrous cycle of the rats in the groups received force in metestrus and diestrus.
Conclusions:
Estrus of rats was the appropriate time for the orthodontic force.
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