Related Experiment Video

Updated: Aug 9, 2026

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

Accelerated atherosclerosis, arterial thromboembolism, and preventive strategies in systemic lupus erythematosus

C C Mok1

  • 1Department of Medicine, Tuen Mun Hospital, Hong Kong, SAR China. ccmok2005@yahoo.com

Scandinavian Journal of Rheumatology
|April 28, 2006
PubMed

Insights

Arterial thromboembolism is a significant cause of illness in patients with systemic lupus erythematosus (SLE). Managing traditional risk factors and using specific medications are crucial for preventing and treating this condition in SLE patients.

Area of Science:

  • Rheumatology
  • Cardiovascular Medicine
  • Immunology

Background:

  • Improved survival in systemic lupus erythematosus (SLE) has shifted focus to other morbidities, including arterial thromboembolism.
  • Accelerated atherosclerosis is a known complication in SLE patients, linked to various risk factors.

Purpose of the Study:

  • To highlight the importance of arterial thromboembolism as a cause of morbidity in SLE.
  • To outline strategies for the prevention and management of arterial thromboembolism in SLE.

Main Methods:

  • Review of conventional and non-conventional risk factors for accelerated atherosclerosis in SLE.
  • Discussion of therapeutic strategies for primary and secondary prevention of arterial thromboembolism.

Main Results:

  • Arterial thromboembolism is a key concern in the long-term management of SLE.
  • Effective management involves controlling traditional risk factors and utilizing specific pharmacological agents.

Conclusions:

  • Regular surveillance and control of traditional risk factors are mandatory for SLE patients.
  • Appropriate use of statins, anti-malarials, anti-platelets, and anti-coagulants is essential for preventing arterial thromboembolism.
  • Judicious use of corticosteroids, calcineurin inhibitors, hormonal replacement therapy, and COX-2 inhibitors is also important.

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...