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Streptococcus pneumoniae isolates resistant to telithromycin.

M Rantala1, M Haanperä-Heikkinen, M Lindgren

  • 1Laboratory of Human Microbial Ecology, National Public Health Institute, Kiinamyllynkatu 13, FIN-20520 Turku, Finland. merja.rantala@ktl.fi

Antimicrobial Agents and Chemotherapy
|April 28, 2006
PubMed
Summary
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Erythromycin-resistant pneumococci can develop resistance to telithromycin. Some bacteria initially showed mixed responses but developed stable, high-level telithromycin resistance upon further culturing.

Area of Science:

  • Microbiology
  • Antimicrobial Resistance

Background:

  • Erythromycin resistance is a growing concern in Streptococcus pneumoniae infections.
  • Telithromycin is a key antibiotic used to treat resistant bacterial infections.
  • Understanding resistance mechanisms is crucial for effective treatment strategies.

Purpose of the Study:

  • To evaluate the susceptibility of erythromycin-resistant pneumococci to telithromycin.
  • To investigate the emergence and stability of telithromycin resistance in these isolates.

Main Methods:

  • Agar diffusion method was used to test telithromycin susceptibility.
  • 210 erythromycin-resistant Streptococcus pneumoniae isolates were analyzed.
  • erm(B)-positive isolates were further cultured to assess resistance stability.

Related Experiment Videos

Main Results:

  • Twenty-six erm(B)-positive isolates exhibited heterogeneous resistance to telithromycin.
  • This heterogeneous resistance was characterized by colonies growing within the inhibition zone.
  • Subsequent culturing of these isolates resulted in stable, homogeneous, high-level telithromycin resistance.

Conclusions:

  • Erythromycin-resistant pneumococci, particularly erm(B)-positive strains, can develop significant telithromycin resistance.
  • Heterogeneous resistance observed initially can evolve into stable, high-level resistance.
  • These findings highlight the importance of monitoring telithromycin resistance in clinical settings.