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Curcumin-artemisinin combination therapy for malaria.

Dalavaikodihalli Nanjaiah Nandakumar1, Viswanathan Arun Nagaraj, Palakkod Govindan Vathsala

  • 1Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India.

Antimicrobial Agents and Chemotherapy
|April 28, 2006
PubMed
Summary

Artemisinin and curcumin exhibit an additive effect against malaria parasites. Combining curcumin with alpha,beta-arteether in mice prevents parasite regrowth and ensures high survival rates.

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Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Parasitology

Background:

  • Artemisinin-based therapies are crucial for malaria treatment.
  • Drug resistance necessitates the exploration of combination therapies.
  • Curcumin, a natural compound, has shown potential antimalarial properties.

Purpose of the Study:

  • To investigate the combined efficacy of artemisinin and curcumin against Plasmodium falciparum.
  • To evaluate the in vivo therapeutic effect of combining curcumin with alpha,beta-arteether in a murine malaria model.

Main Methods:

  • In vitro assessment of artemisinin and curcumin interaction against Plasmodium falciparum cultures.
  • In vivo study using Plasmodium berghei-infected mice treated with alpha,beta-arteether and curcumin.

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Main Results:

  • Artemisinin and curcumin demonstrated an additive interaction in vitro, enhancing parasite killing.
  • In vivo, curcumin administration post-alpha,beta-arteether treatment prevented recrudescence.
  • The combination therapy resulted in nearly 100% survival in infected mice.

Conclusions:

  • Combined artemisinin and curcumin therapy shows significant potential for malaria treatment.
  • Curcumin can overcome alpha,beta-arteether resistance, improving therapeutic outcomes.
  • This combination represents a promising strategy to combat malaria, especially in the face of emerging drug resistance.