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Related Experiment Videos

Paternal age and delivery before 32 weeks.

Olga Basso1, Allen J Wilcox

  • 1Epidemiology Branch, NIEHS (NIH, DHHS), Research Triangle Park, NC 27709, USA. bassoo2@niehs.nih.gov

Epidemiology (Cambridge, Mass.)
|April 28, 2006
PubMed
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Author Reply.

BJOG : an international journal of obstetrics and gynaecology·2026

Advanced paternal age was not linked to early preterm delivery before 32 weeks in this large U.S. study. The findings suggest no increased risk for babies born to older fathers.

Area of Science:

  • Reproductive health
  • Perinatal epidemiology

Background:

  • Advanced paternal age is a growing concern in reproductive health.
  • Previous studies suggested a link between older fathers and early preterm delivery (before 32 weeks gestation).

Purpose of the Study:

  • To investigate the association between advanced paternal age and the risk of early preterm delivery.
  • To provide robust data on paternal age and adverse birth outcomes.

Main Methods:

  • Analysis of over 2.5 million live births from U.S. birth certificates (1995-2000).
  • Focused on white, non-Hispanic married primiparas aged 20-34.
  • Gestational age estimated clinically, excluding improbable birth weights.

Main Results:

  • No statistically significant association was found between advanced paternal age and early preterm delivery.

Related Experiment Videos

  • The highest odds ratio for fathers aged 50+ was 1.3 (95% CI: 0.6-2.8) in the youngest maternal age group (20-24).

    • Conclusions:

    • Current U.S. data do not support a link between advanced paternal age and delivery before 32 weeks.
    • The findings challenge previous associations and highlight the need for further research in diverse populations.