Related Experiment Video
Updated: Aug 9, 2026

Intravascular Delivery of Biologics to the Rat Kidney
Published on: September 1, 2016
Endothelin-1-mediated inflammation in acute renal failure
1School of Nursing and Health Studies, Georgetown University, Washington, DC, USA. angerioa@georgetown.edu
Abstract:
Acute renal failure presents a serious and life-threatening problem in hospitalized patients. Current therapies address the systemic alterations in renal failure. Cellular changes also occur. These changes affect the glomerular filtration rate and the integrity of the glomerular membrane. ET-1, the most potent vasoconstrictor known, has a negative effect on both the rate of filtration and the integrity of the filtering membrane in renal failure. Using ET-1 antagonists along with the current therapies may prove useful in patients.
Related Concept Videos
Acute Kidney Injury II: Pathophysiology
Acute Inflammation III: Local and Systemic Effects
Acute Kidney Injury I: Introduction
Acute Inflammation I: Inflammatory Response
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Inflammation II: Cellular Phase