Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelin-1-mediated inflammation in acute renal failure.

Allan D Angerio1

  • 1School of Nursing and Health Studies, Georgetown University, Washington, DC, USA. angerioa@georgetown.edu

Critical Care Nursing Quarterly
|April 28, 2006
PubMed
Summary

Acute renal failure (ARF) is a critical condition. Endothelin-1 (ET-1) worsens kidney function by impacting filtration and membrane integrity. ET-1 antagonists may improve ARF treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interferon and heart disease.

Critical care nursing quarterly·2009
Same author

Chronic obstructive pulmonary disease and cytokines.

Critical care nursing quarterly·2008
Same author

C-reactive protein, stroke, and statins.

Critical care nursing quarterly·2007
Same author

The role of endothelin in heart failure.

Critical care nursing quarterly·2005
Same author

Inflammatory bowel disease and endothelin-1: a review.

Critical care nursing quarterly·2005
Same author

Sickle cell crisis and endothelin antagonists.

Critical care nursing quarterly·2003

Area of Science:

  • Nephrology
  • Renal Pathophysiology
  • Pharmacology

Background:

  • Acute renal failure (ARF) is a significant clinical challenge, often life-threatening in hospitalized patients.
  • Existing treatments for ARF primarily target systemic issues, but cellular changes are also critical.
  • These cellular alterations negatively impact glomerular filtration rate (GFR) and glomerular membrane integrity.

Purpose of the Study:

  • To investigate the role of Endothelin-1 (ET-1) in the cellular changes associated with ARF.
  • To evaluate the potential therapeutic benefit of ET-1 antagonists in managing ARF.

Main Methods:

  • This study focuses on the pathophysiological mechanisms in acute renal failure.
  • Analysis of the cellular effects of Endothelin-1 (ET-1) on renal function.

Related Experiment Videos

  • Consideration of Endothelin-1 (ET-1) antagonist efficacy in preclinical models or theoretical frameworks.

    • Main Results:

    • Endothelin-1 (ET-1), a potent vasoconstrictor, adversely affects GFR in renal failure.
    • ET-1 compromises the integrity of the glomerular filtering membrane during ARF.
    • Cellular changes in ARF are directly influenced by vasoconstrictive factors like ET-1.

    Conclusions:

    • ET-1 plays a detrimental role in acute renal failure progression by affecting cellular integrity and filtration.
    • Targeting ET-1 with antagonists presents a potential novel therapeutic strategy for ARF.
    • Combination therapy with ET-1 antagonists and current ARF treatments may enhance patient outcomes.