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Published on: July 1, 2018

[Etiology of aseptic meningitis prevalent in Xuzhou]

Xian Li1, Xi-ling Guo, Zhi-yang Shi

  • 1Jiangsu Province Center for Disease Control and Prevention, Nanjing 210009, China.

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology
|April 28, 2006
PubMed
Abstract

Insights

Enterovirus caused aseptic meningitis in Xuzhou, China, in 2001. Coxsackievirus B5 was the predominant serotype identified in cerebrospinal fluid samples.

Area of Science:

  • Virology
  • Epidemiology
  • Infectious Diseases

Context:

  • Aseptic meningitis poses a significant public health challenge.
  • Understanding the etiological agents is crucial for effective disease control.
  • The prevalence of specific viral serotypes can vary geographically and temporally.

Purpose:

  • To identify the causative agents of aseptic meningitis in Xuzhou, Jiangsu Province, during 2001.
  • To determine the predominant enterovirus serotypes responsible for these infections.

Summary:

  • Enterovirus (EV) was identified as the primary pathogen.
  • Coxsackievirus B5 was the most frequently isolated serotype (4 strains), followed by Coxsackievirus B3 (2 strains) and Echovirus 7 (1 strain).
  • Viral RNA detection via RT-PCR and antibody analysis in paired sera confirmed EV infection in a significant proportion of cases.

Impact:

  • This study highlights the role of enteroviruses, particularly Coxsackievirus B5, in aseptic meningitis outbreaks.
  • Findings contribute to the epidemiological surveillance of viral meningitis in the region.
  • Informed public health strategies for prevention and management of enteroviral meningitis.

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