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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Osteoporosis from androgen deprivation therapy in prostate cancer treatment
Nicholas McLeod1, Chi Can Huynh, Prem Rashid
1Department of Urology, Port Macquarie Base Hospital, New South Wales.
Background:
Bone complications from metastatic disease in prostate cancer have been well documented. Osteoporosis from androgen deprivation therapy (ADT) can further impair quality of life in this already susceptible age group.
Objective:
We aimed to assess the intermediate and long term effects of ADT on bone density and the development of osteoporosis in men with prostatic cancer, and outline some practical assessment, management and treatment options.
Discussion:
Osteoporosis, exacerbated by the use of ADT, reduces both the survival and quality of life of men who may otherwise live for many years with their well controlled prostate cancer. Hence, both preventive and treatment options should be explored and tailored to the individual, including lifestyle modifications (exercise, smoking cessation), vitamin D and calcium supplementation, and the use of bisphosphonates.
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