Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cochlear transducer operating point adaptation.

Yuan Zou1, Jiefu Zheng, Tianying Ren

  • 1Oregon Hearing Research Center, NRC04, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239-3098, USA.

The Journal of the Acoustical Society of America
|April 29, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of mitochondrial genomes from three medicinal species of rutaceae and comparative analysis within the family: insights into evolution.

BMC genomics·2026
Same author

Comparison of thickening properties of polysaccharides from four gelatinous edible fungi.

International journal of biological macromolecules·2026
Same author

Detailed pharmacokinetic features of a novel bis-boron <sup>18</sup>F-trifluoroborate acid in healthy volunteers: comparable and additional values of total-body PET-imaging-derived analysis.

European journal of nuclear medicine and molecular imaging·2026
Same author

Discovery and Optimization of Novel Carbazole-Based Ferroptosis Inhibitors.

Chemistry & biodiversity·2026
Same author

The association between tongue features and tongue coating microbiota and gastrointestinal cancer: a systematic review and meta-analysis.

Journal of oral microbiology·2026
Same author

Tuning the Absorption Spectrum of Polydopamine via Post-Synthetic Oxidation with Bobbit's Salt.

Molecules (Basel, Switzerland)·2026

Outer hair cell mechanotransduction operating point shifts were measured using cochlear microphonics. Applied forces altered the operating point, indicating an active mechanism in outer hair cell function.

Area of Science:

  • Auditory Neuroscience
  • Mechanobiology
  • Otoacoustic Emissions

Background:

  • The operating point (OP) of outer hair cell (OHC) mechanotransduction is crucial for hearing sensitivity.
  • Changes in OP can be quantified by shifts in the transduction function, represented as a percentage of maximum transduction current or equivalent ear canal pressure.
  • Cochlear microphonic (CM) harmonics provide a means to assess OP changes.

Purpose of the Study:

  • To investigate the active mechanisms underlying the operating point of OHC mechanotransduction.
  • To determine how mechanical perturbations affect the OHC OP.
  • To characterize the dynamic response of the OHC OP to applied forces.

Main Methods:

  • Measured OHC OP using changes in the second and third harmonics of the cochlear microphonic (CM).

Related Experiment Videos

  • Applied controlled mechanical forces to the cochlear bony shell near the 18 kHz best frequency location.
  • Analyzed the temporal dynamics of CM harmonic recovery following force application and removal.

    • Main Results:

    • The initial OHC OP was found to be dependent on sound level and cochlear sensitivity, measured at 57% of maximum transduction current (–0.1 Pa).
    • Applying force to the scala tympani induced an OP shift towards the scala vestibuli, causing partial recovery of the second CM harmonic with two time constants.
    • Removing the force resulted in a full recovery of the second CM harmonic with a single time constant, while force on the scala vestibuli produced opposite effects.

    Conclusions:

    • These findings demonstrate an active mechanism regulating the operating point of OHC mechanotransduction.
    • The OHC OP is dynamically adjustable in response to mechanical stimuli.
    • CM harmonic analysis is a viable method for probing active cochlear processes.