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Calcinosis circumscripta in a common marmoset (Callithrix jacchus jacchus).

Lynn M Wachtman1, Ashley L Pistorio, Steven Eliades

  • 1Department of Comparative Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Journal of the American Association for Laboratory Animal Science : JAALAS
|April 29, 2006
PubMed
Summary

Calcinosis circumscripta, a rare condition causing mineral deposits, was diagnosed in a common marmoset. This finding is significant due to the species

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Area of Science:

  • Veterinary Pathology
  • Comparative Pathology
  • Primate Medicine

Background:

  • Calcinosis circumscripta is a rare condition characterized by subcutaneous or intradermal deposition of calcium salts.
  • While documented in humans and canids, its occurrence in non-human primates, particularly marmosets, is poorly understood.
  • Understanding the pathogenesis of calcinosis circumscripta in diverse species is crucial for effective diagnosis and management.

Observation:

  • A 2.5-year-old male common marmoset presented with a subcutaneous interscapular mass.
  • Radiographs revealed a radiodense mass near a microchip implant, with fine-needle aspiration yielding chalky, debris-filled liquid.
  • Surgical excision showed the mass infiltrating deep tissues, weighing 30g (10% of body weight).

Findings:

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  • Microscopic examination revealed multifocal mineral aggregates composed of 100% hydroxyapatite, surrounded by inflammatory cells and fibrous tissue.
  • Ectopic bone production was observed focally within the mass.
  • Complete blood count, serum chemistry, and ionized calcium levels excluded systemic metabolic abnormalities.

    • Implications:

    • This case represents the first reported instance of calcinosis circumscripta in the common marmoset (Callithrix jacchus jacchus).
    • The findings are particularly interesting given the marmoset's unique calcium and vitamin D metabolism.
    • Further research into the specific etiologies and metabolic factors contributing to calcinosis circumscripta in this species is warranted.