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Updated: Aug 9, 2026

Synthesis and Mass Spectrometry Analysis of Oligo-peptoids
Published on: February 21, 2018
Fragmentation of protonated peptide ions via interaction with metastable atoms
1MassTech, Inc., Columbia, Maryland 21046, USA. vberkout@apmaldi.com
Abstract:
Fragmentation of protonated peptide ions via interaction with low kinetic energy electronicallyexcited metastable argon atoms was studied in a linear trap-time-of-flight mass spectrometer. Metastable argon atoms were generated using a glow discharge-type source. Protonated peptide ions of substance P, bradykinin, fibrinopetide A, and insulin oxidized chain B were produced by electrospray ionization and trapped in a quadrupole ion guide for 100-400 ms. Intensive series of c- and z-ions were observed in all cases. The kinetic measurements of the fragmentation rates are consistent with calculations of the reaction cross section based on the Landau-Zener approximation.
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