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Caryophyllene sesquiterpenoids from a fungicolous isolate of Pestalotiopsis disseminata
Stephen T Deyrup1, Dale C Swenson, James B Gloer
1Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA.
Abstract:
Three new caryophyllene-type sesquiterpene alcohols, 6-hydroxypunctaporonin E (1), 6-hydroxypunctaporonin B (2), and 6-hydroxypunctaporonin A (3), have been isolated from cultures of the fungicolous fungus Pestalotiopsis disseminata. The structures of 1-3 were determined mainly by analysis of 1D and 2D NMR data. The structure and absolute configuration of 6-hydroxypunctaporonin E (1) was confirmed through X-ray crystallographic analysis of its mono-bromobenzoate derivative. Compounds 1 and 2 showed activity against Gram-positive bacteria.

