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Updated: Aug 9, 2026

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
Published on: June 9, 2017
Proteome analysis to study signal transduction of G protein-coupled receptors
Franka Pluder1, Karin Mörl, Annette G Beck-Sickinger
1Institute of Biochemistry, University of Leipzig, Brüderstrasse 34, D-04103, Leipzig, Germany.
Abstract:
G protein-coupled receptors (GPCR) play an important role in drug development. Although many classical signal transduction pathways have been elucidated, more and more cross-talk to other cascades, e.g. MAP-kinase have been reported. In order to identify the overall function of receptor stimulation in a specific cell type or under certain conditions proteome analysis has been shown to be a very successful and powerful approach. Here, we will summarize the current state of the art of proteome analysis applied to GPCR.
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