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Related Experiment Videos

[Cutaneous leishmaniasis in polymyositis].

I Marie1, C Fevre, L Favennec

  • 1Département de Médecine Interne, CHU Rouen-Boisguillaume, 76031 Rouen cedex, France. isabelle.marie@chu-rouen.fr

La Revue De Medecine Interne
|April 29, 2006
PubMed
Summary

Cutaneous leishmaniasis is an opportunistic infection increasingly seen in immunocompromised individuals. A patient with polymyositis on steroid therapy successfully recovered after intralesional antimony treatment for cutaneous leishmaniasis.

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Area of Science:

  • Infectious Diseases
  • Immunology
  • Dermatology

Background:

  • Cutaneous leishmaniasis (CL) prevalence is rising, particularly in immunocompromised populations.
  • CL is an opportunistic infection often associated with conditions like HIV.
  • Polymyositis and its treatment can compromise immune function, increasing susceptibility to CL.

Observation:

  • A case of cutaneous leishmaniasis in a patient with steroid-refractory polymyositis is presented.
  • The patient's polymyositis and prednisone therapy were identified as predisposing factors for CL.
  • Prednisone therapy may lead to immune dysfunction, including reduced T cell counts and impaired cytokine synthesis.

Findings:

  • Intralesional antimony therapy resulted in a favorable clinical outcome for the patient.

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  • The case highlights the role of iatrogenic immunosuppression in the development of CL.
  • Immune dysfunction, characterized by decreased CD4/CD8 T cells and interferon-gamma, was observed.

    • Implications:

    • This case underscores the importance of recognizing CL in immunocompromised patients, including those with autoimmune diseases on immunosuppressive therapy.
    • Effective treatment options like intralesional antimony should be considered for CL in such cases.
    • Further research into the immunomodulatory effects of immunosuppressive therapies and their link to opportunistic infections is warranted.