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Monoclonal antibody as therapy for malignant lymphomas

Bertrand Coiffier1

  • 1Service d'Hématologie, Hospices Civils de Lyon et Université Claude-Bernard, Lyon-1, CH Lyon-Sud, 69495 Pierre-Bénite, France. bertrand.coiffier@chu-lyon.fr

Comptes Rendus Biologies
|April 29, 2006
PubMed

Rituximab was the first monoclonal antibody to have been registered for the treatment of B-cell lymphomas. Randomized studies have demonstrated its activity in follicular lymphoma, mantle-cell lymphoma, and diffuse large B-cell lymphoma in untreated or relapsing patients. Because of its high activity and low toxicity ratio, rituximab has transformed the outcome of patients with B-cell lymphoma. A combination of rituximab plus chemotherapy, R-CHOP, has the highest efficacy ever described with any chemotherapy in diffuse large B-cell lymphoma and follicular lymphoma. The role of radio-labelled antibodies is still to be defined.

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