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Sex differences in gout epidemiology: evaluation and treatment
L R Harrold1, R A Yood, T R Mikuls
1Meyers Primary Care Institute, University of Massachusetts Medical School, Worcester, MA 01655, USA. HarroldL@ummhc.org
Annals of the Rheumatic Diseases
|April 29, 2006
Summary
Women with gout are older, have more comorbidities, and receive more appropriate serum urate level monitoring. These findings highlight significant differences in gout characteristics and treatment between men and women.
Area of Science:
- Rheumatology
- Epidemiology
- Pharmacology
Background:
- Limited understanding of gout characteristics, evaluation, and treatment in women.
- Gout affects men and women differently, necessitating targeted research.
Purpose of the Study:
- To investigate epidemiological and treatment disparities between men and women with gout.
- To analyze differences in gout management within a large patient population.
Main Methods:
- Retrospective analysis of 1.4 million managed care members (1999-2003).
- Identification of adult members with gout diagnosis (≥2 ambulatory claims).
- Assessment of urate-lowering drug (ULD) initiation and serum urate monitoring.
Main Results:
- 6133 gout patients identified (4975 men, 1158 women).
- Women with gout were older, had more comorbidities, and used diuretics more frequently than men.
- Women were more likely to receive recommended serum urate level testing post-ULD initiation.
Conclusions:
- Women with gout exhibit distinct demographic and clinical profiles compared to men.
- Treatment monitoring, specifically serum urate level surveillance, appears more consistent in women.
- Further research is needed to understand and address gender-specific factors in gout management.
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