Related Experiment Video
Updated: Aug 7, 2026

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
Published on: May 28, 2021
Evolutionary trace report_maker: a new type of service for comparative analysis of proteins
I Mihalek1, I Res, O Lichtarge
1Department of Molecular and Human Genetics, Baylor College of Medicine One Baylor Plaza, Houston, TX 77030, USA. {imihalek,ires,lichtarge}@bcm.tmc.edu
Abstract:
: Evolutionary trace report_maker offers a new type of service for researchers investigating the function of novel proteins. It pools, from different sources, information about protein sequence, structure and elementary annotation, and to that background superimposes inference about the evolutionary behavior of individual residues, using real-valued evolutionary trace method. As its only input it takes a Protein Data Bank identifier or UniProt accession number, and returns a human-readable document in PDF format, supplemented by the original data needed to reproduce the results quoted in the report.
Related Concept Videos
Genome Size and the Evolution of New Genes
Conservation of Protein Domains Over Different Proteins
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Evolutionary Relationships through Genome Comparisons
Ribosome Profiling
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
Protein Folding Quality Check in the RER
Evolution of Microbial Genome

