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Haptoglobin polymorphism in a HIV-1 seropositive Brazilian population

T R Zaccariotto1, E T Rosim, D Melo

  • 1Clinical Pathology Department, School of Medical Sciences, State University of Campinas-UNICAMP, Campinas, São Paulo State, Brazil.

Journal of Clinical Pathology
|April 29, 2006
PubMed
Abstract

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Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
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Hemoglobin

Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
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