Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Multivortex micromixing.

Arjun P Sudarsan¹, Victor M Ugaz

¹Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, TX 77843, USA.

Proceedings of the National Academy of Sciences of the United States of America

|April 29, 2006

Summary

Enhanced micromixing in microchannels is achieved using simple curved and width-changing designs. This method leverages Dean and expansion vortices for efficient fluid mixing in lab-on-a-chip systems.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Biochemically Programmable Isothermal PCR.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2024

Same author

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine.

Lab on a chip·2017

Same author

Smartphone-Enabled Detection Strategies for Portable PCR-Based Diagnostics.

Methods in molecular biology (Clifton, N.J.)·2017

Same author

Synchronized chaotic targeting and acceleration of surface chemistry in prebiotic hydrothermal microenvironments.

Proceedings of the National Academy of Sciences of the United States of America·2017

Same author

Tunable in-situ electro-polymerization of hydrogel films for microchip-based bioanalysis.

Biomicrofluidics·2016

Same author

Characterization of enzymatic micromachining for construction of variable cross-section microchannel topologies.

Biomicrofluidics·2016

Area of Science:

Fluid dynamics
Microfluidics
Biochemical analysis systems

Background:

Efficient liquid mixing is crucial for miniaturized chemical and biochemical analysis systems.
Current microchannel designs often face limitations in achieving rapid and effective mixing.

Purpose of the Study:

To demonstrate enhanced micromixing in simple, planar 2D microchannels.
To utilize channel curvature and width variations to improve mixing efficiency.

Main Methods:

Introducing curvature to induce Dean vortices (vertical plane).
Implementing abrupt width increases to generate expansion vortices (horizontal plane).
Confocal microscopy for visualizing fluorescent dye streams and DNA-dye interactions.

Main Results:

Synergistic effect of Dean and expansion vortices significantly enhances mixing.
Demonstrated efficient mixing through visualization of dye streams.
Confirmed mixing effectiveness via DNA-dye binding interactions.

Conclusions:

Simple geometric modifications (curvature, width changes) in microchannels improve mixing.
The described micromixing strategy is versatile, scalable, and integrable into lab-on-a-chip devices.
This approach offers a straightforward method for enhancing fluid mixing in microfluidic applications.

Related Experiment Videos