Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Trauma-induced systemic inflammatory response versus exercise-induced immunomodulatory effects.

Elvira Fehrenbach1, Marion E Schneider

  • 1Institute of Clinical and Experimental Transfusion Medicine, University of Tuebingen, Tuebingen, Germany. elvira.fehrenbach@med.uni-tuebingen.de

Sports Medicine (Auckland, N.Z.)
|May 2, 2006
PubMed
Summary

Both accidental trauma and strenuous exercise trigger systemic inflammatory response syndrome (SIRS). While exercise-induced SIRS involves heat shock responses, trauma-induced SIRS is linked to tissue damage and immune activation, with exercise promoting a balanced inflammatory response.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coaching to strengthen critical success factors in integrative care for chronic fatigue patients: the Patient Needs-Resources Model.

Frontiers in neuroscience·2023
Same author

Development of a dendrimer PAMAM‑based gold biochip for rapid and sensitive detection of endogenous IFN‑γ and anti‑IFN‑γ IgG in patients with hemophagocytic lymphohistiocytosis.

Molecular medicine reports·2020
Same author

The environmental obesogen bisphenol A increases macrophage self-renewal.

Cell and tissue research·2019
Same author

Development of a novel protein biochip enabling validation of immunological assays and detection of serum IgG and IgM antibodies against Treponema pallidum pathogens in the patients with syphilis.

Biosensors & bioelectronics·2015
Same author

A severe systemic presentation of pigmented villonodular synovitis in a child with underlying Chediak-Higashi syndrome.

Journal of pediatric orthopedics. Part B·2015
Same author

Genetic association of osteopontin (OPN) and its receptor CD44 genes with susceptibility to Chinese gastric cancer patients.

Journal of cancer research and clinical oncology·2014

Area of Science:

  • Physiology
  • Immunology
  • Exercise Science

Background:

  • Systemic inflammatory response syndrome (SIRS) can be triggered by both accidental trauma and strenuous endurance exercise.
  • Exercise-induced SIRS is associated with hyperthermia and heat shock responses.
  • Trauma-induced SIRS involves tissue necrosis, immune activation, and subsequent fever.

Purpose of the Study:

  • To compare the inflammatory and anti-inflammatory cytokine profiles in trauma- versus exercise-induced SIRS.
  • To investigate the role of hyperthermia, heat shock responses, and antioxidant capacity in exercise-induced SIRS.
  • To explore the differences in immune response and susceptibility to infection between trauma and exercise contexts.

Main Methods:

  • Comparative analysis of inflammatory and anti-inflammatory cytokine levels.

Related Experiment Videos

  • Assessment of hyperthermia and heat shock responses.
  • Evaluation of antioxidant capacity and immune competence.

    • Main Results:

    • Both trauma and exercise induce SIRS, but with quantitative differences in inflammatory cytokines.
    • Exercise-induced SIRS is modulated by hyperthermia and heat shock responses, leading to a balanced inflammatory and anti-inflammatory state.
    • Trauma-induced SIRS lacks rest and antioxidant capacity, increasing susceptibility to infections like sepsis, unlike exercise which enhances immune competence.

    Conclusions:

    • Exercise-induced SIRS, unlike trauma-induced SIRS, results in a balanced immune response due to factors like intermittent rest and antioxidant capacity.
    • Regular training may improve immune competence, whereas trauma-induced SIRS can lead to severe complications such as sepsis.
    • Understanding these differential responses is crucial for managing inflammatory conditions and improving patient outcomes.