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Related Experiment Videos

Plasticity from muscle to brain.

Jonathan R Wolpaw1, Jonathan S Carp

  • 1Laboratory of Nervous System Disorders, Wadsworth Center, New York State Department of Health and State University of New York, Albany, 12201, USA. wolpaw@wadsworth.org

Progress in Neurobiology
|May 2, 2006
PubMed
Summary
This summary is machine-generated.

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Sir John Eccles pioneered the understanding of neuroplasticity, demonstrating how the central nervous system (CNS) changes throughout life. His early work on muscles and spinal cord reflexes laid the groundwork for modern neuroscience research.

Area of Science:

  • Neuroscience
  • Neurobiology
  • Central Nervous System (CNS) Plasticity

Background:

  • Historically, neuroscience believed the CNS was largely hardwired, with limited plasticity.
  • Sir John Eccles' early career focused on various forms of plasticity in muscles and the spinal cord.

Discussion:

  • Eccles investigated developmental plasticity, effects of motor unit activity, cross-reinnervation, and axotomy on motoneurons.
  • His research explored functional effects of afferent stimulation and interactions between motoneurons and muscle fibers.
  • He extensively studied spinal reflexes, particularly stretch reflexes, and their plasticity.

Key Insights:

  • Eccles extended his research to plasticity in the hippocampus, cerebellum, and neocortex.
  • His work addressed plasticity related to CNS lesions and the mechanisms of learning and memory.

Related Experiment Videos

  • His observations introduced new research problems and foundational insights for current studies.

    • Outlook:

    • Eccles' contributions anticipated and shaped current hypotheses and experimental designs in neuroscience.
    • His work continues to underpin ongoing basic and clinical research.
    • This review highlights lesser-known aspects of his work relevant to contemporary neuroscience issues.