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Updated: Aug 9, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
Candidaemia in Europe: epidemiology and resistance
Anna Maria Tortorano1, Christopher Kibbler, Javier Peman
1Istituto di Igiene e Medicina Preventiva, Università degli Studi di Milano, Via Pascal 36, 20133 Milan, Italy. annamaria.tortorano@unimi.it
Abstract:
Despite the widespread use of antifungals for prophylaxis, Candida bloodstream infection (BSI) remains the most frequent life-threatening fungal disease. From an analysis of multi-institutional surveys of Candida BSIs performed in Europe, including the large prospective survey by the European Confederation of Medical Mycology (2089 episodes from seven countries), a limited role of species with decreased susceptibility to azoles in causing BSIs and a low proportion of antifungal resistance was evident. Large prospective epidemiological surveys using common databases are needed to monitor trends in incidence and changes in species distribution, to identify new at-risk patients and to evaluate the impact of the introduction into the market of new antifungal agents.
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