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Updated: Aug 9, 2026
04:20
A Saline/Bipolar Radiofrequency Energy Device As an Adjunct for Hemostasis in Solid Organ Injury/Trauma
Published on: July 28, 2020
Pathophysiology of bleeding in surgery
M Marietta1, L Facchini, P Pedrazzi
1Department of Oncology and Hematology, Section Hematology, University of Modena and Reggio Emilia, Modena, Italy. marietta@mail.unimo.it
Transplantation Proceedings
|May 2, 2006
Summary
Surgical bleeding is a major complication, with severe cases increasing mortality risk. Recombinant activated factor VII (rFVIIa) shows promise in managing massive bleeding unresponsive to standard treatments.
Area of Science:
- Surgical Complications
- Hemostasis
- Pharmacology
Background:
- Bleeding is a significant surgical complication, with mortality rates escalating in vascular and major surgeries.
- Excessive blood loss correlates with increased mortality, morbidity, and prolonged intensive care unit stays.
- Technical factors cause most bleeding, but coagulopathies can also contribute.
Purpose of the Study:
- To review the efficacy of recombinant activated factor VII (rFVIIa) in managing surgical bleeding.
- To assess rFVIIa's potential advantage over conventional therapies for massive hemorrhage.
Main Methods:
- Review of existing literature and case reports on rFVIIa use in surgical bleeding.
- Analysis of anecdotal evidence regarding rFVIIa's hemostatic effects.
Main Results:
- Standard treatments for surgical bleeding include source control and hemostatic agents.
- Recombinant activated factor VII (rFVIIa) has been reported effective for massive bleeding unresponsive to conventional therapy.
- Anecdotal reports suggest rFVIIa may offer a hemostatic advantage in complex cases.
Conclusions:
- While most evidence is anecdotal, the reported cases suggest rFVIIa's potential in managing severe surgical bleeding.
- Further investigation may be warranted to confirm rFVIIa's role in specific bleeding scenarios.
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Thromboembolic Disorders
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Thromboembolic Disorders
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