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Updated: Aug 9, 2026

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
Helicobacter pylori: a possible association with otitis media with effusion
Taner Yilmaz1, Mehmet Ceylan, Yakut Akyön
1Department of Otolaryngology-Head and Neck Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey. tyilmaz@hacettepe.edu.tr
Objective:
Evaluate possible role of Helicobacter Pylori in pathogenesis of otitis media with effusion (OME).
Study Design And Setting:
Randomized controlled trial, tertiary referral center.
Study Group:
Middle ear fluid was aspirated, a biopsy was taken from the promontorium of 22 children with OME.
Control Group:
A small biopsy was taken from the promontorium of 20 children with normal otologic findings. For both groups, 5 mm deep tissue specimens were obtained from tonsil and adenoid.
Results:
H pylori presence in the middle ear, the tonsillar and adenoid tissues by culture and PCR was significantly more frequent in the study group compared to the control group (P<0.05).
Conclusions:
This study is the first to grow H pylori in middle ear in OME. Significantly increased colonization by H pylori of the middle ear, and tonsillar and adenoid tissue in patients with OME indicates that the bacteria might be involved in the pathogenesis of OME.
Ebm Rating:
A-1b.
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