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Updated: Aug 9, 2026
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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Laryngeal inflammation assessed using the reflux finding score in obstructive sleep apnea
Richard J Payne1, Karen M Kost, Saul Frenkiel
1Department of Otolaryngology-Head and Neck Surgery, Jewish General Hospital, McGill University, Montreal, Canada. rkpayne@sympatico.ca
Summary
Laryngeal inflammation is common in obstructive sleep apnea (OSA) patients. This inflammation correlates with impaired laryngeal sensation and increased apnea severity.
Area of Science:
- Otolaryngology
- Sleep Medicine
- Gastroenterology
Background:
- Obstructive sleep apnea (OSA) is a common sleep disorder.
- Laryngeal inflammation and sensory dysfunction may be associated with OSA.
- Reflux Finding Score (RFS) and endoscopic sensory testing (EST) are tools to assess laryngeal changes.
Purpose of the Study:
- To investigate the relationship between laryngeal inflammation (RFS), laryngeal sensory function (EST), and OSA severity (apnea-hypopnea index, AHI).
Main Methods:
- 34 patients underwent EST and RFS scoring from video.
- An RFS > 7 indicated increased laryngeal inflammation.
- Correlation analyses were performed between RFS, EST parameters, and AHI.
Main Results:
- 90% of OSA patients (26/29) showed laryngeal inflammation suggestive of laryngopharyngeal reflux.
- Significant correlations were found between inflammation and OSA severity (RFS vs AHI).
- Laryngeal inflammation and sensory impairment were linked, as was the degree of sensory impairment and OSA severity.
Conclusions:
- Laryngeal inflammation is highly prevalent in OSA patients.
- Inflammation is associated with impaired laryngeal sensory function and attenuated laryngeal adductor reflex (LAR).
- OSA severity is correlated with both laryngeal inflammation and sensory dysfunction.
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