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Updated: Aug 9, 2026
04:04
Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
Published on: August 15, 2025
Ameloblastic carcinoma arising from anterior skull base
Samet Ozlugedik1, Muge Ozcan, Olca Basturk
1Department of Otorhinolaryngology, Ankara Numune Research and Training Hospital, Ankara, Turkey. sametozlugedik@yahoo.com
Summary
Ameloblastic carcinoma, an aggressive tumor, rarely originates from the anterior skull base. This case highlights a unique presentation and invasion into the dura mater.
Area of Science:
- Oncology
- Oral and Maxillofacial Surgery
- Pathology
Background:
- Ameloblastic carcinoma (AC) is a rare and aggressive malignant epithelial odontogenic tumor.
- AC can arise de novo or from pre-existing ameloblastoma or odontogenic cysts.
- Odontogenic tumors rarely involve the skull base.
Observation:
- This report details a unique case of AC originating from the anterior skull base.
- The tumor demonstrated invasion into the dura of the anterior cranial fossa.
- This represents the first reported instance of AC in this anatomical location in English literature.
Findings:
- The anterior skull base is an exceptionally rare site for ameloblastic carcinoma.
- Invasion into adjacent structures like the dura mater signifies advanced disease.
- Clinical course and treatment strategies for skull base AC require careful consideration.
Implications:
- This case expands the known anatomical distribution of ameloblastic carcinoma.
- It underscores the importance of considering rare origins for skull base tumors.
- Further research is needed to understand the behavior and optimal management of AC in this location.
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