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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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Type I phosphoinositide 3-kinases: potential antithrombotic targets?

S F Jackson1, S M Schoenwaelder

  • 1Australian Centre for Blood Diseases, Monash University, 6th Level Burnet Building, Alfred Medical Research and Education Precinct (AMREP), 89 Commercial Road, Melbourne, Victoria, 3004, Australia. Shaun.Jackson@med.monash.edu.au

Cellular and Molecular Life Sciences : CMLS
|May 2, 2006
PubMed
Summary

Targeting phosphoinositide 3-kinases (PI3Ks) in platelets may offer a novel antithrombotic strategy. Inhibiting specific PI3K isoforms reduces arterial thrombosis without increasing bleeding risk.

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