Related Experiment Video
Updated: Aug 9, 2026

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
Published on: November 24, 2021
Branched-chain alkanols as skin permeation enhancers: quantitative structure-activity relationships
Abstract:
One long-standing approach for improving transdermal drug delivery is using penetration enhancers which reversibly decrease the skin barrier resistance. Though the skin permeation enhancement effect of chemical penetration enhancers has been studied extensively, their quantitative structure-activity relationships have not been adequately investigated. In this paper, we established the correlation equations between enhancement potencies and the physico-chemical parameters relevant to lipophilicity and position of hydroxyl group for 16 alkanols using the stepwise multiple linear regression analysis. These equations reveal that the enhancement potencies of alkanols are excellently correlated with their lipophilicity and position of the hydroxyl group. The enhancement potency of an alkanol will increase when it has greater lipophilicity but will decrease as the hydroxyl group moves from the end of the alkyl chain towards the center.
Related Concept Videos
Physical Properties of Alkanes
Nomenclature of Alkanes
The alkane nomenclature considers the length of the carbon chain, the number, and the location of the substituent to arrive at its systematic name. The IUPAC...
Constitutional Isomers of Alkanes
The linear isomer of an alkane is prefixed by the term “n”; hence a linear isomer of pentane is known as n-pentane. Based on the type of branching, some of the branched isomers are given...
Structure of Alkanes
Hydrocarbons are the simplest organic compounds composed of carbons and hydrogens. Based on the bond order between carbons, the hydrocarbons are further classified into alkanes, alkenes, and alkynes.
Alkanes are the simplest hydrocarbons with sp3 hybrid carbon atoms. These sp3...
Mass Spectrometry: Branched Alkane Fragmentation
Local Anesthetics: Chemistry and Structure-Activity Relationship
